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By: I. Peer, M.B. B.CH. B.A.O., M.B.B.Ch., Ph.D.

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Glaxo counters that the phrase "copper ions in an amount sufficient to degrade" should be construed according to its plain meaning infection 2 tips order generic colchicine on line. According to Glaxo virus in california generic colchicine 0.5 mg with mastercard, the specification and the prosecution history contain numerous references to the "trace" or "minute" amounts of copper ions that have a destabilizing effect on immunoglobulins virustotal buy genuine colchicine line. Therefore antibiotics for nodular acne colchicine 0.5mg for sale, Glaxo argues that the - 1824 - Jump to: A­ B­ C­ D­ E ­ F­ G­ H­ I­ J­ K­ L­ M­ N­ O­ P­ Q­ R­ S­T­ U­V­W­ X­Y­ Z court should construe "copper ions in an amount sufficient to degrade" to mean enough copper to degrade whether or not the copper is detectable. Rather, the specification states that "it may be that the presence of copper ions in amounts below the detection limits of techniques such as atomic absorption spectroscopy still has a destabilizing effect on the immunoglobulin which can be eliminated by the addition of a suitable chelating agent. The phrase at issue was apparently added to the claims after the applicants and the examiner agreed during an interview that an "amendment regarding the level of copper" would probably overcome the obviousness rejection. In the amendment that followed, the applicants stated that the phrase, copper ions in an amount sufficient to degrade, "makes explicit that which was implicit in the claim before, namely, that the composition of IgG1 immunoglobulin also contains copper ions. After reviewing the specification and the prosecution history, the court finds that the phrase, "copper ions in an amount sufficient to degrade," should be construed according to its plain meaning. The inventors did not set forth an alternative definition of the phrase in the specification or in the prosecution history. Therefore, the court finds that the phrase "copper ions in an amount sufficient to degrade" requires enough copper ions to degrade. Genentech specifically argues that the cooper ions must actually degrade the accused composition when the copper ions present in the composition are not bound by the chelator. Glaxo counters that the phrase requires enough copper ions to degrade by cleaving the IgG 1 immunoglobulin into fragments. After reviewing the specification and file histories of the patents, the court sees no reason to modify the plain meaning construction of the phrase it set forth in Glaxo. As a result and for the reasons stated in Glaxo, the phrase "copper ions in an amount sufficient to degrade" requires enough copper ions to degrade IgG 1 immunoglobulin. Koslow explains that his invention applies pressures in excess of 400 psi while Degen applies "exceedingly low" pressures, "most preferred maximum 40 psi. Accordingly, it describes process conditions well outside the range of compression utilized in the present invention, which would be 400-1000 psi. Without such higher pressures, the binder resins are not activated and the novel structures produced by the current invention are not obtained. The specification of Degen states that "pressures in the range of up to the crush strength of the carbon, which is about 400 psi, are suitable although, from a practical perspective, pressures up to about 40 psi are preferred. Koslow distinguished his invention from Degen on the basis that his invention applies pressures greater than 400 psi. Koslow did not clearly set forth an alternative definition in the specification or file history. The description of the prior art observes that a disadvantage of prior art dental bleaching products and techniques is "that the bleaching agent must be frequently replaced during the day" and that "saliva dilution and swallowing of the bleaching agent cause[s] the volume of agent the tray to diminish rapidly over time, thereby decreasing the amount of active ingredient available for tooth bleaching. This further indicates that the claim is drawn to a long-lasting composition that provides constant levels of bleaching. The specification also states that compositions within the scope of the patent have such high viscosity that positive pressure is needed to dispense them from their containers, such as a syringe or a squeeze tube. In contrast, the specification observes that existing low viscosity bleaching agents can be dispensed drop-wise from a bottle. While somewhat illustrative of the initial viscosity of formulations which may fall within the scope of the patent, this specification cannot be read into the claims. The viscosity of the composition as it is dispensed into a dental tray is of only limited importance to the objects of the invention. The claimed inventions are improved methods and compositions that remain viscous for long periods of time and dilute more slowly in saliva. Thus, a very viscous composition that is dispensed with a syringe but which quickly loses its viscosity and dilutes rapidly in saliva might not be within the scope of the invention, while an initially less viscous material that is resistant to dilution or perhaps even reacts with saliva to become more viscous over time might be within the scope of claim 1. Thus, this court declines to limit claim 1 based on how a composition may be dispensed into the dental tray. Instead, the language of claim 1 must be interpreted in light of the specification language that states that "the present invention. The context here is, as Examiner Fourson noted, a highly unpredictable chemical art. The court concludes that the applicants did not use "reasonably precise" terms to describe the invention of claim 24 in light of the subject matter.

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Manufacturers will build their devices around several different possible operating systems antibiotic resistance development purchase colchicine 0.5 mg without prescription, including Mee-Go by Nokia and Android infection while pregnant discount colchicine 0.5mg visa. Services like this provide an interface for merchants to make goods and services available for clients to bid on infection endocarditis purchase colchicine with amex. In general infections of the skin discount 0.5 mg colchicine visa, you can think of cloud computing as being any service that is offered outside of a company and is available to users from many different areas. When looking at cloud computing, you need to consider three components: the front end, the back end, and middle ware. To access services in the cloud the front end must have: · Access to the network containing the cloud: this access usually is to the Internet. On the back end lies the infrastructure including the servers, storage devices, applications, etc. Because of the nature of cloud computing, service providers generally warehouse robust systems capable of providing the processing power necessary to deliver services. Additionally, the service provider is responsible for ensuring services are available to clients at any point so they generally maintain a high level of redundancy. You have, too, if you have an e-mail account outside of your company, like Hotmail, Yahoo Mail, or Gmail. To get to any of these e-mail services, you have to use your own hardware, like your laptop, to access the network containing the services. You also have to use special software to access the service, usually a web browser. On the back end the e-mail provider provides the e-mail capability along with the security features that allow you to access your e-mail account, and prevents others from unauthorized access. The service provider also provides all the storage necessary to store your e-mail until you clean out your inbox. When considering service providers, take the time to find out how they plan on securing your data and restricting access to those you authorize. The middleware is responsible for allowing communications between systems within an interaction between the front and back ends. Middleware is a specialized software application that administers the interaction between the front end and back end. With the middleware a central server can monitor traffic and route requests appropriately. There are a number of smartphone models available today from various manufactures, but only a few operating systems. Section 10-4 · Various smart devices are available today that provide smaller, handheld platforms on which to perform many computer type activities, including accessing wireless networks. Section 10-2 · Remote access generally requires one or more remote access server and a set of clients requiring access. Which packet-switched connection method supports the highest bandwidth connections? Which protocol is used for Windows client dial-in remote access to a Windows server? You are designing a remote access solution for a company with three sets of requirements: · Field service personnel need as flexible a connection method as possible that will work from nearly any location-five users total. Researcher time requirements vary depending on whether they are gathering information or processing the data. When configuring support for field service personnel, what is needed at the client end? The office will be set up as part of the same Windows Active Directory domain as the main office. What are your options to correct the problem if the connection becomes saturated as the remote office grows? Reliability and access to data in any location are critical concerns, and a failure at any one location should not prevent other locations from communicating. You want to be able to specify the exact topology used to connect with remote offices with a determinate path between the offices. You estimate the current peak bandwidth requirements as 1 Mbps between each office and the other four offices. Requirements can vary from month to month and are their highest at end of quarter and end of year.

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Of the nonbenzenoid surface-active agents for which individual statistics are shown in the table antibiotic handbook purchase genuine colchicine on line, those produced in largest quantity were glycerol monostearate antibiotic 93 purchase cheapest colchicine and colchicine, 31 million pounds; coconut oil acids-diethanolamine condensate (amine/ acid ratio-1/1) antibiotics for acne while breastfeeding colchicine 0.5 mg otc, 17 million pounds; and dodecyl sulfate bacteria resistant to antibiotics order colchicine australia, sodium salt, 13 million pounds. Polyethoxyethyl dioleate Polyethoxyethyl distearate Polyethoxyethyl monolaurate Polyethqxyethyl mono-oleate Polyethoxyethyl monostearate Polyethoxyethyl tall oil ester All other See 47 Value Unit value 2 Per pound 1,000 pounds 1,000 pounds 1,000 dollars 579,786 120,625 3,255 1,782 1,473 86,945 26,747 17,450 4,269 5,028 8,488 1,603 753 2,602 1,522 2,193. Ethers, not sulfated or sulfonated, total Polyethylene glycol ethers, total Polyethoxyethyl castor oil ether Polyethoxyethyl dodecyl ether Polyethoxyethyl octadecyl ether Polyethoxyethyl oleyl ether Polyethoxyethyl tridecyl ether All other All other ethers and thioethers Fatty acids, potassium and sodium salts, not sulfated or sulfonated, total Coconut oil acids, potassium salt Oleic acid, potassium salt Oleic acid, sodium saltStearic acid, potassium salt Tall oil acids, potassium salt Tallow acids, sodium salt All other Phosphoric and polyphosphoric acid esters, not sulfated or sulfonatedu Sulfated and sulfonated nonbenzenoid surface-active agents, total Dicarboxylic acid amides and esters, sulfated and sulfonated, total Di(2-ethylhexyl)sulfosuccinate All other Fats, oils, and waxes, sulfated and sulfonated, total Castor oil, sulfonated Coconut oil, sulfonated Cod oil, sulfonated Lard, sulfonated Neatsfoot oil, sulfonated Peanut oil, sulfonated Rice-bran oil, sulfonated Soybean oil, sulfonated Sperm oil, sulfonated Tall oil, sulfonated Tallow, sulfonated All other Other nonbenzenoid surface-active agents, sulfated and sulfonated, total Coconut oil acids-monoethanolamine condensate, sulfated, potassium salt See 1,000 pounds 1,000 pounds 1,000 dollars Per pound 21,501 45 785 20,671 85,918 60,168 1,801. Includes ethoxylated alkylphenols and small quantities of other benzenoid esters and ethers. Includes tridecylbenzenesulfonates and salts of all other benzene-, toluene-, and xylenesulfonates. Includes octylphenoxypolyethoxyethanesulfonic acid, sodium salt of water-soluble petroleumsulfonic acid, and sulfonated derivatives of biphenyl and of diphenyl ether. The data are given in terms of 100-percent active material; they thus exclude such materials as diluents, emulsifiers, synergists, and wetting agents. Statistics on production and sales of pesticides and other organic agricultural chemicals in 1961 are given in table 21A. Sales in 1961 were 612 million pounds, valued at $303 million, compared with 570 million pounds, valued at $262 million, in 1960. The output of cyclic pesticides and other chemicals included in the cyclic group amounted to 572 million pounds in 1961-about 9 percent more than the 526 million pounds produced in 1960. Sales in 1961 were 484 million pounds, valued at $238 million, compared with 455 million pounds, valued at $203 million, in 1960. Production of acyclic pesticides and other acyclic organic agricultural chemicals in 1961 amounted to 128 million pounds, compared with the 122 million pounds reported for 1960. Sales in 1961 were 128 million pounds, valued at $65 million, compared with 115 million pounds, valued at $59 million, in 1960. Production of the gamma isomer content in benzene hexachloride and lindane totaled 7. The 1961 production of Ziram was 1,099,000 pounds; sales amounted to 1,075,000 pounds, valued at $816,000. These miscellaneous chemicals, which account for about three-fifths of the output of all synthetic organic chemicals, include products that are employed in a great variety of uses; the number of chemicals used exclusively for only one purpose is not large. Among the products covered are those used for gasoline and lubricating oil additives, paint driers, photographic chemicals, tanning materials, flotation reagents, refrigerants, textile polymers, sequestering agents, organic fertilizers, antifreeze chemicals, solvents, and acyclic intermediates. Statistics on production and sales of miscellaneous chemicals in 1961 are given in table 22A. Sales in 1961 totaled 431 million pounds, valued at $146 million, compared with 435 million pounds, valued at $165 million, in 1960. The most important subgroup of cyclic compounds was the lubricating oil additives, the output of which was 348 million pounds in 1961. Production of alcohols and halogenated hydrocarbons in 1961 each exceeded that of any of the use groups of synthetic organic chemicals except cyclic intermediates and plastics and resin materials. Alcohols are used as solvents, intermediates, and antifreeze materials, and for other purposes. Halogenated hydrocarbons are used as solvents, intermediates, refrigerants, and aerosol propellants, and for other purposes. Individual miscellaneous chemicals the output of which exceeded 1 billion pounds in 1961 were synthetic methanol (2. All other Sodium formaldehydesulfoxylate Sodium methoxide (Sodium methylate) Stearic acid salts, total? Aluminum stearates, total Aluminum distearate Aluminum stearate, other Ammonium stearate Barium stearate Calcium stearate Lead stearate Lithium stearate Magnesium stearate Zinc stearate All other Tallow amide, hydrogenated Triethylene glycol Urea in compounds or mixtures (100% basis), total 8 In feed compounds In liquid fertilizer In solid fertilizer All other Vinyl acetate monomer desulfoxylate Zinc formaldehy All other miscellaneous acyclic chemicals 1 2 Value 1,000 dollars Unit value l Per pound 1,000 pounds 1,000 pounds 4,555 160,341 374,153 22,354 2,756 578 11,072 4,553 3,395 5,493 4,268 27,299 5,298 4,273 1,025 321 294 8,433 441 261 1,088 7,705 3,458 1,382 30,183 1,843,573 203,010 626,311 842,670 171,582 273,491 1,223 7,048,231 4,695 122,141 35,655. Statistics on copper naphthenate are given in the section "Pesticides and Other Organic Agricultural Chemicals. The tables include data on only those chemicals for which the volume of production or sales in 1961 exceeded 1,000 pounds or for which the value of sales exceeded $1, 000. The manufacturers of each product are indicated by identification codes which are listed in the Directory of Manufacturers (table 23). A few companies, however, have specifically requested that they not be identified as having produced or sold certain items.

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Cottonseed hulls Wheat bran Gypsum Magnesium sulfate Water Cottonseed hulls Corncobs Wheat bran Gypsum Urea Water 100 kg 20-25 kg 4 kg 0 antibiotic for bronchitis purchase colchicine visa. Preparation of Substrate For mixing the substrate ingredients infection after hysterectomy buy colchicine 0.5 mg amex, the magnesium sulfate or urea should first be dissolved in water antibiotic abbreviation buy 0.5 mg colchicine free shipping, and at the same time a small amount of water should be added to the corncobs and/or cottonseed hulls bacteria 4 plus purchase 0.5 mg colchicine overnight delivery. After the corncobs and cottonseed hulls have accepted water and become wetted, the wheat bran and gypsum should be mixed in. Then the remainder of the water should be added and the substrate mixed thoroughly. Filling the Bags To avoid fermentation and the formation of acid, which would affect the pH of the substrate, the bags should be filled on the same day that the substrate is mixed. The operations, starting with the beginning of mixing to the final filling of the bags, should be completed within 6 hours. Initially, the bag is a plastic tubing, one end of which is tied with string before filling. The bag is then filled by hand or by machine, and, when the bag is full, the other end is tied. The surface of the bag is cleaned by wiping it with cheesecloth, following which four to five holes are punched in the bag with a borer that is 15 mm in diameter. These holes, which will be used for inoculation of the substrate, should be 2 cm deep. Sterilization the bags are placed in a sterilization chamber at a temperature that is slightly less than 100C for 8 to 10 hours. An alternative procedure is to sterilize the filled bag first; and, after it has cooled, punch the holes, inoculate, and seal the holes with tape. Inoculation the bags are ready for inoculation when the bag temperature drops below 28C. The inoculation room should be rendered as free as possible from contaminants by wiping the working surfaces with a disinfectant solution and freeing the air of microorganisms by vapors of a germicide. First, the old mycelium at the top of the spawn bottle should be cut off with a knife and discarded. Then, the spawn that extends 3 cm into the bottle should be crumbled to make a uniform distribution of the spawn mycelium. After removing the tape squares covering the holes, forceps should be used to insert a peanut-sized piece of spawn into each inoculation hole in the bag. Mycelial Running the inoculated bags should be kept in an incubation room at 28 to 30C for 1 to 4 days after inoculation. By 5 to 10 days after inoculation, mycelium will have grown from the inoculum and penetrated into the substrate, and at this time the temperature should be lowered to 26C and the relative humidity should not be greater than 70%. The bags should now be placed on the beds, separated from one another by 1 to 2 cm. Management for Fruiting Body Formation Approximately 10 days after inoculation, a round-shaped growth of mycelium will appear from the inoculation site. At this point the tape should be opened slightly for aeration, the room temperature should be dropped to 20 to 25C, and the relative humidity raised to 80 to 85%. Every day the windows should be opened four to five times for ventilation, and each time they should be kept open for 15 to 20 minutes. When this happens, the tape squares that cover the inoculation sites should be removed and the bags covered with newspapers. After 1 to 2 days later the holes at the inoculation sites should be enlarged by cutting 1 cm more of the bag around each hole. The enlarged hole permits greater ventilation and facilitates growth of the fruiting bodies. If the room temperature is greater than 25C, the newspapers covering the plastic bags and empty places in the mushroom house should be sprinkled with water to lower the temperature to 25C, but care should be taken not to overwater because this can cause damage to the fruiting bodies. Under the normal management procedures described, mushrooms will appear 18 days after inoculation. The shape of the mature fruiting body is like that of a chrysanthemum flower, with a diameter reaching 8 to 12 cm. The mushrooms emerge from holes in the bags where the spawn was introduced into the substrate. At the other extreme, if the mushrooms are harvested too late, the base of the fruiting body will become blackened, and it may start to decay ж affecting adversely the quality of the mushroom. A sharp knife should be used to cut the structure attaching the fruiting body to the compost.

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